The primary objective of this clinical study was to evaluate the effect of a dietary\nmultivitamin, multimineral and phytonutrient (VMP) supplement on blood nutrient status and\nbiomarkers of heart health risk in a Russian population. One hundred twenty healthy adults\n(40ââ?¬â??70 years) were recruited for a 56-day (eight-week) randomized, double blind, placebo controlled\nstudy with parallel design. Subjects were divided into two groups and received either a VMP\nor a placebo (PLA) supplement. Blood nutrient levels of Ã?²-carotene, Ã?±-tocopherol, vitamin C,\nB6, B12, red blood cell (RBC) folate, Zinc and Selenium were measured at baseline and on Days\n28 and 56, and quercetin was measured at baseline and on Day 56. Blood biomarkers of heart\nhealth, i.e. homocysteine (Hcy), high-sensitivity C-reactive protein (hs-CRP), oxidized LDL (ox-LDL),\ngamma-glutamyl transferase (GGT), uric acid and blood lipid profile, were measured at baseline\nand Day 56. Dietary VMP supplementation for 56 days significantly increased circulating levels of\nquercetin, vitamin C, RBC folate and partially prevented the decline in vitamin B6 and B12 status.\nBoth serum Hcy and GGT were significantly reduced (âË?â??3.97 Ã?± 10.09 Ã?¼mol/L; âË?â??1.68 Ã?± 14.53 U/L,\nrespectively) after VMP supplementation compared to baseline. Dietary VMP supplementation\nimproved the nutrient status and reduced biomarkers of heart health risk in a Russian population.
Loading....